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Dec062010

Video - David Lominadze - "Microcirculation, Role of Fibrinogen - 11_11_2009

Abstract: Fibrinogen (Fg) is a well known marker of inflammation. It is also known as an inflammatory agent. The slightest elevation of its content in plasma increases the risk of cardiovascular complications associated with diseases such as hypertension, diabetes, and stroke. In addition, it was found that Fg hinders autoimmune reaction and complicates targeting of cancer cells for treatment. However, little is known regarding the effects of Fg in microcirculation and in various blood circulatory pathologies. This presentation is intended to show the mechanisms of Fg effects on vascular reactivity, regulated production of endothelin-1 (ET-1), endothelial cells (ECs), EC integrity, erythrocyte aggregation, and platelet thrombogenesis. Specifically, I will discuss mechanisms of Fg-activated extracellular signal- regulated kinases-1 and 2 (ERK-1/2) signaling leading to exocytosis of Weibel-Palade bodies, formation of filamentous actin (F-actin) in ECs, and changes in expression of endothelial tight junction proteins. Effects of Fg on activation of metalloproteinases (MMPs), formation of oxygen radical species in ECs, and changes of EC proteome will also be shown. Possible applications of nano-technology in assessment of Fg interaction with ECs, platelets, and erythrocytes, as well as methods to measure blood cell-to-cell interaction forces will be discussed.

Biography:  Dr. David Lominadze has been an Assistant Professor, tenure track, in the Department of Physiology and Biophysics, University of Louisville since 2008. He has a B.S. and MS in Physics/Biophysics from the Tbilisi State University, Tbilisi, Georgia. He completed his Ph.D. at the Institute of Physiology, Georgian Academy of Sciences (Tbilisi, Georgia) where he worked on changes of blood rheological properties in microvessels. He held the position of Head of Microrheology Sector, Microcirculation Research Center at the Institute of Physiology as he came to the Center for Applied Microcirculatory Research, University of Louisville, as an Adjunct Assistant Professor in 1992. Since then he has worked on changes of platelet thrombogenesis and red blood cell aggregability during copper deficiency and hypertension. Dr. Lominadze returned to Louisville in 1999 after he left the USA 8 months earlier. Since then he developed a research program related to changes in platelet thrombogenesis and erythrocyte aggregability during hypertension development, for which he was granted a National Scientist Development Award from the American Heart Association in 2002. Focusing his research on the role of Fg in microcirculation during hypertension, he received funding from the National Heart and Blood Institute in 2006. Dr. Lominadze’s research is focused on mechanisms involved in Fg and EC, platelet, and erythrocyte interactions, effects of Fg on vascular responses, remodeling, and permeability. He is a collaborator on NIH funded projects by Drs. Suresh C. Tyagi (Univ. of Louisville) and Menq-Jer Lee (Wayne State University).

 

 

 

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